Just before 11 p.m. Saturday, officers responded to a disturbance in the 4700 block of University Way NE.
When officers arrived, they found a man had been stabbed in the torso, Kappel said.
Fire Department medics transported the victim to Harborview Medical Center, where he died.
The only suspect description available at this time is a tall, thin black male, Kappel said.
Police said the events leading up to the stabbing are unknown and under active investigation.
Anyone with information about the stabbing or who may know the identity or whereabouts of the suspect is asked to call 911 or the Seattle Police Homicide Tip Line at (206) 233-5000.